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1

A revival of bispecific antibodies

Peter Kufer, Ralf Lutterbüse, Patrick A. Baeuerle

Journal:

Trends in Biotechnology

Year:

2004

Language:

english

File:

PDF, 358 KB

english, 2004

2

Strictly Target Cell-dependent Activation of T Cells by Bispecific Single-chain Antibody Constructs of the BiTE Class

Brischwein, Klaus, Parr, Larissa, Pflanz, Stefan, Volkland, Jörg, Lumsden, John, Klinger, Matthias, Locher, Mathias, Hammond, Scott A., Kiener, Peter, Kufer, Peter, Schlereth, Bernd, Baeuerle, Patrick

Journal:

Journal of Immunotherapy

Year:

2007

Language:

english

File:

PDF, 361 KB

english, 2007

3

In vitro and in vivo activity of MT201, a fully human monoclonal antibody for pancarcinoma treatment

Stefanie Naundorf, Susanne Preithner, Petra Mayer, Sandra Lippold, Andreas Wolf, Frank Hanakam, Iduna Fichtner, Peter Kufer, Tobias Raum, Gert Riethmüller, Patrick A. Baeuerle, Torsten Dreier

Journal:

International Journal of Cancer

Year:

2002

Language:

english

File:

PDF, 326 KB

english, 2002

4

Extremely potent, rapid and costimulation-independent cytotoxic T-cell response against lymphoma cells catalyzed by a single-chain bispecific antibody

Torsten Dreier, Grit Lorenczewski, Christian Brandl, Patrick Hoffmann, Uwe Syring, Frank Hanakam, Peter Kufer, Gert Riethmuller, Ralf Bargou, Patrick A. Baeuerle

Journal:

International Journal of Cancer

Year:

2002

Language:

english

File:

PDF, 199 KB

english, 2002

5

Serial killing of tumor cells by cytotoxic T cells redirected with a CD19-/CD3-bispecific single-chain antibody construct

Patrick Hoffmann, Robert Hofmeister, Klaus Brischwein, Christian Brandl, Sandrine Crommer, Ralf Bargou, Christian Itin, Nadja Prang, Patrick A. Baeuerle

Journal:

International Journal of Cancer

Year:

2005

Language:

english

File:

PDF, 359 KB

english, 2005

6

Immunomodulatory therapy of cancer with T cell-engaging BiTE antibody blinatumomab

Dirk Nagorsen, Patrick A. Baeuerle

Journal:

Experimental Cell Research

Year:

2011

Language:

english

File:

PDF, 542 KB

english, 2011

7

CD19-/CD3-bispecific antibody of the BiTE class is far superior to tandem diabody with respect to redirected tumor cell lysis

Michael Mølhøj, Sandrine Crommer, Klaus Brischwein, Doris Rau, Mirnaalini Sriskandarajah, Patrick Hoffmann, Peter Kufer, Robert Hofmeister, Patrick A. Baeuerle

Journal:

Molecular Immunology

Year:

2007

Language:

english

File:

PDF, 792 KB

english, 2007

8

Antiviral Activity of HIV gp120 Targeting Bispecific T Cell Engager (BiTE®) Antibody Constructs

Brozy, Johannes, Schlaepfer, Erika, Mueller, Christina K. S., Rochat, Mary-Aude, Rampini, Silvana K., Myburgh, Renier, Raum, Tobias, Kufer, Peter, Baeuerle, Patrick A., Muenz, Markus, Speck, Roberto F

Journal:

Journal of Virology

Year:

2018

Language:

english

File:

PDF, 892 KB

english, 2018

9

Pharmacokinetic and Pharmacodynamic Relationship of Blinatumomab in Patients with Non-Hodgkin Lymphoma

Hijazi, Youssef, Klinger, Matthias, Kratzer, Andrea, Wu, Benjamin, Baeuerle, Patrick A., Kufer, Peter, Wolf, Andreas, Nagorsen, Dirk, Zhu, Min

Journal:

Current Clinical Pharmacology

Year:

2018

Language:

english

File:

PDF, 3.91 MB

english, 2018

10

Phenotype and function of human dendritic cells derived from M-DC8+ monocytes

Annegret de Baey, Ines Mende, Gert Riethmueller, Patrick A. Baeuerle

Journal:

European Journal of Immunology

Year:

2001

Language:

english

File:

PDF, 150 KB

english, 2001

11

Oxygen and the control of gene expression

Heike L. Pahl, Patrick A. Baeuerle

Journal:

Year:

1994

Language:

english

File:

PDF, 834 KB

english, 1994

12

Hydrogen peroxide as a potent activator of T lymphocyte functions

Marek Los, Wulf Dröge, Kirstin Stricker, Patrick A. Baeuerle, Klaus Schulze-Osthoff

Journal:

European Journal of Immunology

Year:

1995

Language:

english

File:

PDF, 894 KB

english, 1995

13

Severe combined immunodeficiency due to defective binding of the nuclear factor of activated T cells in T lymphocytes of two male siblings

Stefan Feske, Judith M. Müller, Daniel Graf, Richard A. Kroczek, Ruth Dräger, Charlotte Niemeyer, Patrick A. Baeuerle, Hans-Hartmut Peter, Michael Schlesier

Journal:

European Journal of Immunology

Year:

1996

Language:

english

File:

PDF, 932 KB

english, 1996

14

Differential activation of transcription factors NF-ϰB and AP-1 in rat liver macrophages

Thuy-Anh Tran-Thi, Karl Decker, Patrick A. Baeuerle

Journal:

Year:

1995

Language:

english

File:

PDF, 796 KB

english, 1995

15

Efficient tumor cell lysis by autologous, tumor-resident T lymphocytes in primary ovarian cancer samples by an EP-CAM-/CD3-bispecific antibody

Pauline Wimberger, Wei Xiang, Doris Mayr, Joachim Diebold, Torsten Dreier, Patrick A. Baeuerle, Rainer Kimmig

Journal:

International Journal of Cancer

Year:

2003

Language:

english

File:

PDF, 229 KB

english, 2003

16

The Histidine Tail of Recombinant DNA Binding Proteins May Influence the Quality of Interaction with DNA

Hildegard Büning, Ulrike Gärtner, David von Schack, Patrick A. Baeuerle, Haralabos Zorbas

Journal:

Analytical Biochemistry

Year:

1996

Language:

english

File:

PDF, 145 KB

english, 1996

17

Expression of epithelial cellular adhesion molecule (Ep-CAM) in chronic (necro-)inflammatory liver diseases and hepatocellular carcinoma

Kai Breuhahn, Patrick A. Baeuerle, Malte Peters, Nadja Prang, Ulrich Töx, Rudolph Köhne-Volland, Volker Dries, Peter Schirmacher, Eugen Leo

Journal:

Hepatology Research

Year:

2006

Language:

english

File:

PDF, 661 KB

english, 2006

18

The roles of hydrogen peroxide and superoxide as messengers in the activation of transcription factor NF-κB

Kerstin N. Schmidt, Paul Amstad, Peter Cerutti, Patrick A. Baeuerle

Journal:

Chemistry & Biology

Year:

1995

Language:

english

File:

PDF, 2.04 MB

english, 1995

19

Combination of rituximab with blinatumomab (MT103/MEDI-538), a T cell-engaging CD19-/CD3-bispecific antibody, for highly efficient lysis of human B lymphoma cells

Sandrine d’Argouges, Sandra Wissing, Christian Brandl, Nadja Prang, Ralf Lutterbuese, Alex Kozhich, JoAnn Suzich, Mathias Locher, Peter Kiener, Peter Kufer, Robert Hofmeister, Patrick A. Baeuerle, Ral

Journal:

Leukemia Research

Year:

2009

Language:

english

File:

PDF, 815 KB

english, 2009

20

Novel antineoplastic agents with efficacy against multidrug resistant tumor cells

Julio C. Medina, Bei Shan, Holger Beckmann, Robert P. Farrell, David L. Clark, R. Marc Learned, Daniel Roche, Angela Li, Vijay Baichwal, Casey Case, Patrick A. Baeuerle, Terry Rosen, Juan C. Jaen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 204 KB

english, 1998

21

Interleukin-1β Uses Common and Distinct Signaling Pathways for Induction of the Interleukin-6 and Tumor Necrosis Factor α Genes in the Human Astrocytoma Cell Line U373

Klaus Lieb, Christian Kaltschmidt, Barbara Kaltschmidt, Patrick A. Baeuerle, Mathias Berger, Joachim Bauer, Bernd L. Fiebich

Journal:

Journal of Neurochemistry

Year:

1996

Language:

english

File:

PDF, 1.16 MB

english, 1996

22

Side-by-side analysis of five clinically tested anti-EpCAM monoclonal antibodies

Markus Münz, Alexander Murr, Majk Kvesic, Doris Rau, Susanne Mangold, Stefan Pflanz, John Lumsden, Jörg Volkland, Jan Fagerberg, Gert Riethmüller, Dominik Rüttinger, Peter Kufer, Patrick A Baeuerle, T

Journal:

Cancer Cell International

Year:

2010

Language:

english

File:

PDF, 1.25 MB

english, 2010

23

Developmental and tissue-specific expression of theQ5kgene

Sabine Schwemmle, Dorian Bevec, Gottfried Brem, Manuela B. Urban, Patrick A. Baeuerle, Elisabeth H. Weiss

Journal:

Year:

1991

Language:

english

File:

PDF, 1.05 MB

english, 1991

24

Structural analysis, expression, and chromosomal localization of the mouseikbagene

R. A. Rupec, Dominique Poujol, Josiane Grosgeorge, Georges F. Carle, Antonia Livolsi, Jean-François Peyron, Roland M. Schmid, Patrick A. Baeuerle, Gerald Messer

Journal:

Year:

1999

Language:

english

File:

PDF, 362 KB

english, 1999

25

Epithelial tight junction proteins as potential antibody targets for pancarcinoma therapy

Sonja Offner, Armin Hekele, Ulrike Teichmann, Susanne Weinberger, Susanne Gross, Peter Kufer, Christian Itin, Patrick A. Baeuerle, Birgit Kohleisen

Journal:

Cancer Immunology, Immunotherapy

Year:

2005

Language:

english

File:

PDF, 1.83 MB

english, 2005

26

Exchanging human Fcγ1 with murine Fcγ2a highly potentiates anti-tumor activity of anti-EpCAM antibody adecatumumab in a syngeneic mouse lung metastasis model

Petra Lutterbuese, Klaus Brischwein, Robert Hofmeister, Sandrine Crommer, Grit Lorenczewski, Laetitia Petersen, Sandra Lippold, Antonio da Silva, Mathias Locher, Patrick A. Baeuerle, Bernd Schlereth

Journal:

Cancer Immunology, Immunotherapy

Year:

2007

Language:

english

File:

PDF, 368 KB

english, 2007

27

The effect of dexamethasone on polyclonal T cell activation and redirected target cell lysis as induced by a CD19/CD3-bispecific single-chain antibody construct

Christian Brandl, Cornelia Haas, Sandrine d’Argouges, Tanja Fisch, Peter Kufer, Klaus Brischwein, Nadja Prang, Ralf Bargou, JoAnn Suzich, Patrick A. Baeuerle, Robert Hofmeister

Journal:

Cancer Immunology, Immunotherapy

Year:

2007

Language:

english

File:

PDF, 431 KB

english, 2007

28

Therapeutic window of an EpCAM/CD3-specific BiTE antibody in mice is determined by a subpopulation of EpCAM-expressing lymphocytes that is absent in humans

Maria Amann, Matthias Friedrich, Petra Lutterbuese, Eva Vieser, Grit Lorenczewski, Laetitia Petersen, Klaus Brischwein, Peter Kufer, Roman Kischel, Patrick A. Baeuerle, Bernd Schlereth

Journal:

Cancer Immunology, Immunotherapy

Year:

2009

Language:

english

File:

PDF, 672 KB

english, 2009

29

Epitope distance to the target cell membrane and antigen size determine the potency of T cell-mediated lysis by BiTE antibodies specific for a large melanoma surface antigen

Claudia Bluemel, Susanne Hausmann, Petra Fluhr, Mirnalini Sriskandarajah, William B. Stallcup, Patrick A. Baeuerle, Peter Kufer

Journal:

Cancer Immunology, Immunotherapy

Year:

2010

Language:

english

File:

PDF, 514 KB

english, 2010

30

Myocardial gene expression of matched hibernating and control tissue from patients with ischemic left ventricular dysfunction

Dietlind Zohlnhöfer, Thomas G. Nührenberg, Felix Haas, Frank Bengel, Albert Schömig, Patrick A. Baeuerle, Markus Schwaiger

Journal:

Heart and Vessels

Year:

2008

Language:

english

File:

PDF, 683 KB

english, 2008

31

Cytotoxic activity of novel human monoclonal antibody MT201 against primary ovarian tumor cells

Wei Xiang, Pauline Wimberger, Torsten Dreier, Joachim Diebold, Doris Mayr, Patrick A. Baeuerle, Rainer Kimmig

Journal:

Journal of Cancer Research and Clinical Oncology

Year:

2003

Language:

english

File:

PDF, 417 KB

english, 2003

32

Lysis of cancer cells by autologous T cells in breast cancer pleural effusates treated with anti-EpCAM BiTE antibody MT110

Juliane Witthauer, Bernd Schlereth, Klaus Brischwein, Hauke Winter, Ilona Funke, Karl-Walter Jauch, Patrick Baeuerle, Barbara Mayer

Journal:

Breast Cancer Research and Treatment

Year:

2009

Language:

english

File:

PDF, 471 KB

english, 2009

33

10.1038/26254

Baeuerle, Patrick A., Cohen, Lucie, Henzel, William J.

Journal:

Year:

1998

Language:

english

File:

PDF, 409 KB

english, 1998

34

Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB

Henkel, Thomas, Machleidt, Thomas, Alkalay, Irit, Krönke, Martin, Ben-Neriah, Yinon, Baeuerle, Patrick A.

Journal:

Year:

1993

File:

PDF, 590 KB

1993

35

Enter a polypeptide messenger

Baeuerle, Patrick A.

Journal:

Year:

1995

File:

PDF, 291 KB

1995

36

Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis

Los, Marek, Craen, Marc Van de, Penning, Louis C., Schenk, Heike, Westendorp, Michael, Baeuerle, Patrick A., Dröge, Wulf, Krammer, Peter H., Fiers, Walter, Schulze-Osthoff, Klaus

Journal:

Year:

1995

File:

PDF, 369 KB

1995

37

Nuclear signalling by tumour-associated antigen EpCAM

Maetzel, Dorothea, Denzel, Sabine, Mack, Brigitte, Canis, Martin, Went, Philip, Benk, Michael, Kieu, Cuong, Papior, Peer, Baeuerle, Patrick A., Munz, Markus

Journal:

Nature Cell Biology

Year:

2009

Language:

english

File:

PDF, 2.89 MB

english, 2009

38

On the abundance of EpCAM on cancer stem cells

Gires, Olivier, Klein, Christoph A., Baeuerle, Patrick A.

Journal:

Nature Reviews Cancer

Year:

2009

Language:

english

File:

PDF, 130 KB

english, 2009

39

Regulation of the transcription factors NF-κB and AP-1 by redox changes

Markus Meyer, Heike L. Pahl, Patrick A. Baeuerle

Journal:

Chemico-Biological Interactions

Year:

1994

Language:

english

File:

PDF, 561 KB

english, 1994

40

The inducible transcription activator NF-κB: regulation by distinct protein subunits

Patrick A. Baeuerle

Journal:

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

Year:

1991

Language:

english

File:

PDF, 1.80 MB

english, 1991

41

A role for oxygen radicals as second messengers

Ralf Schreck, Patrick A. Baeuerle

Journal:

Trends in Cell Biology

Year:

1991

Language:

english

File:

PDF, 386 KB

english, 1991

42

Proteins controlling the nuclear uptake of NF-κB, Rel and dorsal

M.Lienhard Schmitz, Thomas Henkel, Patrick A. Baeuerle

Journal:

Trends in Cell Biology

Year:

1991

Language:

english

File:

PDF, 1017 KB

english, 1991

43

Lipopolysaccharide-induced lung inflammation is inhibited by neutralization of GM-CSF

Ruzica Puljic, Ewald Benediktus, Christine Plater-Zyberk, Patrick A. Baeuerle, Stefan Szelenyi, Kay Brune, Andreas Pahl

Journal:

European Journal of Pharmacology

Year:

2007

Language:

english

File:

PDF, 464 KB

english, 2007

44

Overexpression of epithelial cell adhesion molecule (Ep-CAM) is an independent prognostic marker for reduced survival of patients with epithelial ovarian cancer

Gilbert Spizzo, Philip Went, Stephan Dirnhofer, Peter Obrist, Holger Moch, Patrick A. Baeuerle, Elisabeth Mueller-Holzner, Christian Marth, Guenther Gastl, Alain G. Zeimet

Journal:

Gynecologic Oncology

Year:

2006

Language:

english

File:

PDF, 291 KB

english, 2006

45

Recent advances torwards understanding redox mechanisms in the activation of nuclear factor κb

Yvonne M.W Janssen-Heininger, Matthew E Poynter, Patrick A Baeuerle

Journal:

Free Radical Biology and Medicine

Year:

2000

Language:

english

File:

PDF, 523 KB

english, 2000

46

Activation of Human Immunodeficiency Virus Long Terminal Repeat by Arachidonic Acid

Rita Carini, Gabriella Leonarduzzi, Simonetta Camandola, Tiziana Musso, Luigi Varesio, Patrick A Baeuerle, Giuseppe Poli

Journal:

Free Radical Biology and Medicine

Year:

1997

Language:

english

File:

PDF, 313 KB

english, 1997

47

Apoptosis: Activate NF-κB or die?

Vijay R Baichwal, Patrick A Baeuerle

Journal:

Current Biology

Year:

1997

Language:

english

File:

PDF, 158 KB

english, 1997

48

Pro-inflammatory signaling: Last pieces in the NF-κB puzzle?

Patrick A Baeuerle

Journal:

Current Biology

Year:

1998

Language:

english

File:

PDF, 81 KB

english, 1998

49

Endoplasmicreticulum-induced signal transduction and gene expression

Heiki L. Pahl, Patrick A. Baeuerle

Journal:

Trends in Cell Biology

Year:

1997

Language:

english

File:

PDF, 822 KB

english, 1997

50

The ER-overload response: activation of NF-κB

Heike L. Pahl, Patrick A. Baeuerle

Journal:

Trends in Biochemical Sciences

Year:

1997

Language:

english

File:

PDF, 1.18 MB

english, 1997